The speech neuroprosthesis – Nature.com

Summary

Lack of speech after paralysis is devastating, however circumventing motor-pathway harm by straight decoding speech from intact cortical exercise has the potential to revive pure communication and self-expression. Latest discoveries have outlined how key options of speech manufacturing are facilitated by the coordinated exercise of vocal-tract articulatory and motor-planning cortical representations. On this Evaluation, we spotlight such progress and the way it has led to profitable speech decoding, first in people implanted with intracranial electrodes for medical epilepsy monitoring and subsequently in people with paralysis as a part of early feasibility medical trials to revive speech. We focus on high-spatiotemporal-resolution neural interfaces and the difference of state-of-the-art speech computational algorithms which have pushed fast and substantial progress in decoding neural exercise into textual content, audible speech, and facial actions. Though restoring pure speech is a long-term aim, speech neuroprostheses have already got efficiency ranges that surpass communication charges supplied by present assistive-communication know-how. Given this accelerated price of progress within the area, we suggest key analysis metrics for pace and accuracy, amongst others, to assist standardize throughout research. We end by highlighting a number of instructions to extra totally discover the multidimensional function area of speech and language, which can proceed to speed up progress in the direction of a clinically viable speech neuroprosthesis.

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Fig. 1: Key milestones in speech decoding.
Fig. 2: Articulatory management of speech.
Fig. 3: Decoding speech from neural exercise.
Fig. 4: Evaluating and standardizing speech neuroprostheses.

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Acknowledgements

The authors are extremely grateful to the many individuals who enrolled within the aforedescribed research. A.B.S. was supported by the Nationwide Institute on Deafness and Different Communication Problems of the Nationwide Institutes of Well being beneath award quantity F30DC021872. Ok.T.L. is supported by the Nationwide Science Basis GRFP. J.R.L. and D.A.M. had been supported by the Nationwide Institutes of Well being grant U01 DC018671-01A1.

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Authors and Affiliations

Authors

Contributions

E.F.C. and A.B.S. researched knowledge for the article and contributed considerably to dialogue of the content material. All authors wrote the article and reviewed and/or edited the manuscript earlier than submission.

Corresponding writer

Correspondence to
Edward F. Chang.

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Competing pursuits

D.A.M., J.R.L. and E.F.C. are inventors on a pending provisional UCSF patent utility that’s related to the neural-decoding approaches surveyed on this work. E.F.C. is an inventor on patent utility PCT/US2020/028926, D.A.M. and E.F.C. are inventors on patent utility PCT/US2020/043706 and E.F.C. is an inventor on patent US9905239B2, that are broadly related to the neural-decoding approaches surveyed on this work. EFC is co-founder of Echo Neurotechnologies, LLC. All different authors declare no competing pursuits.

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Nature Opinions Neuroscience thanks Gregory Cogan, who co-reviewed with Suseendrakumar Duraivel; Marcel van Gerven; Christian Herff; and Cynthia Chestek for his or her contribution to the peer assessment of this work.

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Supplementary info

Supplementary Data

Glossary

Anarthria

Speech-motor dysfunction referring to an incapability to maneuver the vocal-tract muscle groups to articulate speech.

Aphasias

A dysfunction of understanding or expressing language.

Tried speech

That is an instruction given to people with vocal-tract paralysis to aim to talk one of the best they will, regardless of lack of the try being intelligible.

Concatenative synthesizer

A speech-synthesis method that depends on matching neural exercise with discrete items of a speech waveform which can be then concatenated collectively.

Corticobulbar system

The pathway by which motor instructions from the cortex attain the muscle groups of the vocal tract. At a excessive degree, cortical motor neurons ship axons by way of the corticobulbar tract which terminate in cranial nerve nuclei within the brainstem. Second-order motor neurons within the cranial nerve nuclei then ship axons, that bundle and type cranial nerves, to innervate the muscle groups of the vocal tract.

Formants

The popular resonating frequencies of the vocal tract which can be vital for forming totally different vowel sounds.

Language fashions

Fashions which can be skilled to seize the statistical patterns of phrase occurrences in pure language.

Locked-in syndrome

This refers to a medical situation wherein a participant retains cognitive capability however has restricted voluntary motor perform. Locked-in syndrome is a spectrum, starting from totally locked in states (no residual voluntary motor perform) to partially locked in states (some residual voluntary motor perform resembling head actions).

Mime

An try to maneuver vocal-tract muscle groups with out making an attempt to vocalize.

Sensorimotor cortex

This space of the cortex consists of the precentral and postcentral gyri, primarily chargeable for motor management and sensation, respectively.

Silently tried speech

That is an instruction given to people with vocal-tract paralysis to aim to talk one of the best they will, however with out vocalizing.

Speech articulators

The vocal-tract muscle teams which can be vital for producing (articulating) speech, together with the lips, jaw, tongue and larynx.

Syntax

The association and construction of phrases to type coherent sentences.

Vocal-tract paralysis

An incapability to contract and transfer the speech articulators, typically brought on by harm to descending motor-neuron tracts within the brainstem.

Zipf’s legislation

The legislation that usually proposes that the frequencies of things are inversely proportional to their ranks.

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Cite this text

Silva, A.B., Littlejohn, Ok.T., Liu, J.R. et al. The speech neuroprosthesis.
Nat. Rev. Neurosci. (2024). https://doi.org/10.1038/s41583-024-00819-9

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  • Accepted: 12 April 2024

  • Revealed: 14 Could 2024

  • DOI: https://doi.org/10.1038/s41583-024-00819-9

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